Bryan Johnson is a billionaire who built Venmo, sold it to PayPal, and now invests roughly $1.5 million per year with the goal of reverting his body to the biological age of 18. His project is called “Blueprint” — he uses himself as a test subject, pursuing a scientifically optimized lifestyle. As a teacher, I can barely afford $75 a month on supplements, let alone $1.5 million, but I’ve extracted the principles from his protocol that can be applied for free or at low cost.
I’ve spent a lot of time researching this topic, and here’s what I found.
I’ve spent a lot of time researching this topic, and here’s what I found.
Ever noticed this pattern in your own life?
Ever noticed this pattern in your own life?
What Is Bryan Johnson’s Blueprint?
Blueprint is a self-optimization experiment Johnson began in 2021. He undergoes dozens of blood tests, MRIs, and various physical measurements every month, working with a team of over 100 doctors and scientists to slow or reverse aging across every bodily system [1].
I believe this deserves more attention than it gets.
Related: sleep optimization blueprint
The key metrics he tracks include:
Last updated: 2026-04-03
Your Next Steps
- Today: Pick one idea from this article and try it before bed tonight.
- This week: Track your results for 5 days — even a simple notes app works.
- Next 30 days: Review what worked, drop what didn’t, and build your personal system.
Disclaimer: This article is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with any questions about a medical condition.
About the Author
Written by the Rational Growth editorial team. Our health and psychology content is informed by peer-reviewed research, clinical guidelines, and real-world experience. We follow strict editorial standards and cite primary sources throughout.
References
- Johnson B. (2023). Blueprint Protocol. blueprint.bryanjohnson.com. Accessed 2026.
- López-Otín C, et al. (2023). Hallmarks of aging: An expanding universe. Cell, 186(2), 243-278.
- de Cabo R, Mattson MP. (2019). Effects of intermittent fasting on health, aging, and disease. New England Journal of Medicine, 381(26), 2541-2551.
- Walker M. (2017). Why We Sleep: Unlocking the Power of Sleep and Dreams. Scribner.
- Kaeberlein M. (2018). How healthy is the healthspan concept? GeroScience, 40(4), 361-364.
Disclaimer: This article is for informational purposes only and does not substitute for medical advice. Do not take prescription medications such as rapamycin or metformin without a doctor’s prescription. This
